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KMID : 0384920090180010044
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Korean Journal of Occupational Health Nursing
2009 Volume.18 No. 1 p.44 ~ p.54
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Effects of Obesity on the Physiological Levels of Adiponectin, Leptin and Diagnostic Indices of Metabolic Syndrome in Male Workers
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Heo Kyung-Hwa
Ko Kyung-Sun
Kim Ki-Woong
Won Yong-Lim
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Abstract
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Purpose: The aim of this study was to examine the effects of obesity on the physiological levels of adiponectin, leptin and components of metabolic syndrome (MS) in male workers, aged 30-40 years.
Methods: Body mass index (BMI) was measured with Anthropometric equipment. Blood pressure and serum parameters were measured with an automatic digital sphygmomanometer and autochemical analyzer, respectively. Adiponectin and leptin were analysed by ELISA kits and MS was defined based on the NCEP-ATP III.
Results: Body fat mass of waist and hip, systolic and diastolic blood pressure were significantly higher, as expected, in the BMI＞ 25㎏/㎡ in comparison with the BMI≤25㎏/㎡. While fasting glucose, insulin, HOMA-IR and leptin in the BMI＞25㎏/㎡ were also significantly higher compared with BMI≤25㎏/㎡, HDL- cholesterol and adiponectin were significantly higher in BMI≤25㎏/㎡. On multiple logistic regression analysis for the components of MS, exercise, adiponectin and leptin were an only independent factor for MS in non-obese male workers(BMI≤25㎏/㎡) after adjustment for age, cigarette smoking and drinking habits.
Conclusion: These results suggested that the obesity in men was associated with physiological levels of adiponectin and leptin contributing to feedback control of MS and that dysfunction and/or declination in feedback control system associated with changes in physiological levels of neurptrophics: adiponectin and leptin might ultimately induce MS.
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KEYWORD
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Metabolic syndrome, Adiponectin, Leptin, Male workers
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